A retrospective analysis of 48 patients with confirmed frontal lobe epilepsy (FLE) examined the occurrence of secondary generalized tonic-clonic seizures (SGTCS). Three independent predictors of a history of SGTCS in FLE were identified:
- Loss of responsiveness at seizure onset
- A semiology involving early elementary motor signs
- Multifocal spikes on EEG.
Seizure-free outcomes were reported in 57% of surgical cases and were more likely in those without SGTCS.
Baud MO, Vulliemoz S, Seeck M. Recurrent secondary generalization in frontal lobe epilepsy: predictors and a potential link to surgical outcome [published online ahead of print July 25, 2015]? Epilepsia. 2015; doi: 10.1111/epi.13086.