Literature Review

Does TBI-Induced Inflammation Contribute to Seizure Development

IL-1β gene variability implicated in PTE risk



In a study of 256 patients with moderate-to-severe traumatic brain injury (TBI), researchers showed that higher cerebral spinal fluid and serum interleukin- 1beta (IL-1β) ratios were associated with increased risk of posttraumatic epilepsy (PTE). This is the first report of its type and results provide evidence that biologic variability with blood-brain barrier integrity during recovery from TBI could be attributed to genetic and IL-1β genetic and ratio associations with PTE. Further studies are needed to confirm these findings.

Diamond ML, Ritter AC, Failla MD, et al. IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study. Epilepsia. 2015;56(7):991-1001.

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