Literature Review

Is MEG a Valuable Tool for Interictal Spike Mapping before Epilepsy Surgery?

A retrospective cohort study evaluates 132 postsurgical epilepsy patients



A retrospective cohort study of 132 patients with focal epilepsy who received MEG and underwent resective surgery found that magnetoencephalography (MEG) was a valuable tool for noninvasive interictal spike mapping. Prior to the results of this study, the clinical utility of MEG in presurgical evaluation of patients with epilepsy was not fully understood because of the lack of long-term outcomes or small sample sizes. The reliability of MEG was comparable in patients with or without localized scalp EEG and the use of MEG to localize the epileptogenic zone was associated with improved seizure outcomes.

Englot DJ, Nagarajan SS, Imber BS, et al. Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery [published online ahead of print April 29, 2015]. Epilepsia. 2015:doi:10.1111/epi.13002.

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