Literature Review

Do Memory and Mood Affect AED Adherence?

Physicians may be able to identify patients at greater risk of nonadherence



In a cross-sectional study, one hundred patients with epilepsy on antiepileptic drug (AED) therapy were observed to determine adherence to treatment. Patients in the adherent group—65% of the population—were found to have significantly lower depression scores compared with the nonadherent group. Memory scores were not robustly correlated with adherence. The authors conclude that physicians should consider targeting patients with epilepsy and comorbid depression as they may be at a higher risk of nonadherence.

McAuley JW, Passen N, Prusa C, Dixon J, Cotterman-Hart S, Shneker BF. An evaluation of the impact of memory and mood on antiepileptic drug adherence. Epilepsy Behav. 2015;43:61-65.

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