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Sex, Race Differences in Ischemic Stroke Examined

JAMA Neurology; ePub 2018 Dec 10; Howard, et al

For both blacks and whites, at age 45 through 64 years, women were at lower ischemic stroke risk than men, and there was no sex difference at ≥75 years; however, the sex difference pattern may differ by race from age 65 through 74 years. This according to a recent study that examined incidence and risk factors for ischemic stroke by sex for black and white individuals.

This prospective study included participants aged ≥45 years who were stroke-free from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Researchers found:

  • 25,789 participants (14,170 women [54.9%]; 10,301 blacks [39.9%]) were included.
  • During 222,120 person-years of follow-up, 939 ischemic strokes occurred: 159 (16.9%) in black men, 326 in white men (34.7%), 217 in black women (23.1%), and 237 in white women (25.2%).
  • Between the ages of 45 and 64, white women had 32% lower stroke risk than white men, and black women had a 28% lower risk than black men.
  • Lower stroke risk in women than men persisted at age 65 through 74 years in white individuals, but not in black individuals; however, the race-sex interaction was not significant.

Howard VJ, Madsen TE, Kleindorfer DO, et al. Sex and race differences in the association of incident ischemic stroke with risk factors. [Published online ahead of print December 10, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.3862.