Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Proximity to Major Roadway, Stroke Risk Linked

Stroke; ePub 2018 Mar 14; Kulick, et al

In a recent urban multiethnic cohort study, there was evidence supporting that within-city variation in residential proximity to a major roadway is associated with higher risk of ischemic stroke. However, an individual’s smoking history modified this association, with the association remaining only among participants not currently smokers. Subjects (n=3,287) participated in NOMAS (The Northern Manhattan Study), an ongoing, population-based cohort study designed to measure cardiovascular risk factors, stroke incidence, and other outcomes in a multiethnic urban population. Recruitment occurred from 1993 to 2001 and participants are followed-up annually by telephone. Researchers found:

  • During a median follow-up period of 15 years, 11% of participants were diagnosed with ischemic stroke.
  • Participants living <100 m from a roadway had a 42% higher rate of ischemic stroke vs those living >400 m.
  • This association was more pronounced among noncurrent smokers and not evident among smokers.
  • There was no clear pattern of association between proximity to major roadways and other cardiovascular events including myocardial infarction, all-cause death, or vascular death.

Kulick ER, Wellenius GA, Boehme AK, Sacco RL, Elkind MS. Residential proximity to major roadways and risk of incident ischemic stroke in NOMAS (The Northern Manhattan Study). [Published online ahead of print March 14, 2018]. Stroke. doi:10.1161/STROKEAHA.117.019580.