Clinical Edge

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Cigarette Smoking and Functional Outcomes in ICH

Stroke; 2019 Mar; Chen, Ding, Ironside, et al

Cigarette smoking history does not seem to provide a beneficial effect on 90-day functional outcome in patients with intracerebral hemorrhage (ICH), according to a recent study. Researchers analyzed prospectively collected data from the Ethnic/Racial Variations of Intracerebral Hemorrhage study and included patients with smoking status data in the analysis. Patients were dichotomized into non-smokers vs ever-smokers, and the latter group was further categorized as former (>30 days before ICH) or current (≤30 days before ICH) smokers. They found:

  • The overall study cohort comprised 1,509 non-smokers and 1,423 ever-smokers (841 former, 577 current, 5 unknown).
  • No difference in primary outcome was observed between non-smokers vs ever-smokers (adjusted odds ratio [aOR], 1.041).
  • No differences in primary outcome were observed between former (aOR, 0.932) or current smokers (aOR, 1.178) vs non-smokers.
  • Subgroup analyses by race/ethnicity demonstrated no differences in primary outcome when former and current smokers were compared with non-smokers.
  • Former, but not current, smokers had a lower in-hospital mortality rate (aOR, 0.695), which was only observed in Hispanics (aOR, 0.533).
  • Differences in self-reported health status measures were only observed in whites.


Chen C-J, Ding D, Ironside N, et al. Cigarette smoking history and functional outcomes after spontaneous intracerebral hemorrhage. Stroke. 2019;50(3):588-594. doi:10.1161/STROKEAHA.118.023580.