Among healthy middle-aged adults, the presence of sleep apnea at baseline did not accelerate kidney function decline compared to those without sleep apnea over time, a recent study found. Researchers performed a retrospective cohort study of 855 participants from the Wisconsin Sleep Cohort Study (WSCS), a large 20-year population-based study of sleep apnea, who had at least 1 polysomnogram and serial measurements of serum creatinine over time. Sleep apnea was defined as an apnea-hypopnea index ≥15 or positive airway pressure (PAP) use at baseline. The mean follow-up was 13.9 ± 3.4 years. The cohort was 50.4 ±7.6 years, 55% male, and 97% white. They found:
- The mean eGFR was 89.3 ±13.8 ml/min/1.73m2 and 11% had sleep apnea.
- Overall, the mean eGFR change was -0.88 ± 1.12 ml/min/1.73m2/year.
- Compared to those without sleep apnea, participants with sleep apnea had a 0.2 ml/min/1.73m2/year slower eGFR decline though this was not statistically significant.
Canales MT, Hagen EW, Barnet JH, Peppard PE, Derose SF. Sleep apnea and kidney function trajectory: Results from a 20-year longitudinal study of healthy middle-aged adults. [Published online ahead of print November 3, 2017]. Sleep. doi:10.1093/sleep/zsx181.