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Prior head injury is associated with severe Parkinson’s disease phenotype

Key clinical point: Head injury before onset of Parkinson’s disease is associated with more severe motor and nonmotor phenotypes.

Major finding: In one cohort, the mean MDS-UPDRS-I score was 7.73 in patients with prior head injury and 6.19 in patients without injury.

Study details: An online survey of two cohorts of patients with Parkinson’s disease.

Disclosures: The Parkinson’s Progression Markers Initiative and the Fox Insight study are funded by the Michael J. Fox Foundation. Dr. Brown has received compensation from HiOscar, NEJM Knowledge Plus, and Rune Labs.


Brown EG et al. AAN 2020. Abstract S17.002.