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Aneurysm Linked with Fibromuscular Dysplasia in Women

JAMA Neurol; ePub 2017 Jul 17; Lather, et al

The prevalence of intracranial aneurysm in women diagnosed with fibromuscular dysplasia (FMD) is significantly higher than reported in the general population, according to a recent study. This cross-sectional study included women with intracranial imaging registered in the US Registry for Fibromuscular Dysplasia, an observational disease-based registry of patients with FMD confirmed by vascular imaging and currently enrolled at 14 participating US academic centers. Researchers found:

  • Of 1,112 female patients in the registry, 669 (60.2%) had undergone intracranial imaging at the time of enrollment (mean [SD] age at enrollment, 55.6 [10.9] years).
  • Of the 669 patients included in the analysis, 86 (12.9%) had at least 1 intracranial aneurysm.
  • Of these 86 patients, 25 (53.8%) had more than 1 intracranial aneurysm.
  • Intracranial aneurysms ≥5 mm occurred in 32 of 74 patients (43.2%), and 24 of 128 intracranial aneurysms (18.8%) were in the posterior communicating or posterior arteries.
  • A history of smoking was significantly associated with intracranial aneurysm: 42 of 78 patients with intracranial aneurysm (53.8%) had a smoking history vs 163 of 564 patients without intracranial aneurysm (28.9%).


Later HD, Gornik HL, Olin JW, et al. Prevalence of intracranial aneurysm in women with fibromuscular dysplasia. A report from the US Registry for Fibromuscular Dysplasia. [Published online ahead of print July 17, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.1333.