Key clinical point: First-degree relatives of individuals with amyotrophic lateral sclerosis have elevated risk of developing the disease.
Major finding: The lifetime risk for ALS among first-degree relatives of individuals with the disease was 1.4%, compared with 0.3% in the general population (P less than .001).
Study details: Prospective, population-based cohort study of 1,117 patients with incident ALS.
Disclosures: Dr. Ryan and one coauthor reported receiving funding from Science Foundation Ireland, and one coauthor reported receiving book royalties from Taylor & Francis, and fees from Cytokinetics and Waves Pharmaceuticals. The study was funded by Science Foundation Ireland and the Motor Neurone Disease Association.
Ryan M et al. JAMA Neurol. 2019 Jul 22. doi: 10.1001/jamaneurol.2019.2044.