Clinical Edge

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Which Interventions Can Treat Cognitive Fatigue?

Key clinical point: Only one intervention – transcranial direct current stimulation (tDCS) – has been found to counteract cognitive fatigability in a trial with objective outcome measures.

Major finding: Compared with sham stimulation, anodal tDCS increased P300 amplitude and reduced fatigue-related decrements in reaction time in a preliminary study.

Study details: A systematic review of intervention studies that objectively measured cognitive fatigability in adults with neurologic disorders.

Disclosures: The authors had no disclosures.


Lindsay-Brown A et al. CMSC 2019, Abstract NNN10.