Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Turning: Important Marker of Gait and Balance in MS

PLoS One; ePub 2018 Jun 7; Adusumilli, Lancia, et al

The 25-Foot Times Walk Test, the standard straight-line gait assessment for multiple sclerosis (MS,) may not reflect adequately upon balance and coordination, according to a recent study. Walking tests with turns, however, may add additional information towards understanding gait and balance status, and be more reflective of ambulation. 91 persons with MS were enrolled in an initial cross-sectional study, with 24 subjects completed a follow-up visit an average of 12 months later. Spatiotemporal gait analysis was collected at both visits using APDM Opal wireless body-worn sensors while performing the Timed-Up-and-Go (TUG) and 6-Minute Walk Test (6MWT). Researchers found:

  • The addition of 6MWT peak turn velocity (PTV) to 6MWT stride velocity (SV) increased the predictive power of the 6MWT for the Activities-Specific Balance Confidence Scale (ABC) from 20% to 33%, and increased the predictive power from 28% to 41% for the multiple Sclerosis Walking Scale (MSWS)-12.
  • TUG PTV added to TUG SV also strengthened the relationship of the TUG for the ABC from 19% to 28%, and 27% to 36% for the MSWS-12.

Adusumilli G, Lancia S, Levasseur VA, et al. Turning is an important marker of balance confidence and walking limitation in persons with multiple sclerosis. [Published online ahead of print June 7, 2018]. PLoS One. doi:10.1371/journal.pone.0198178.

This Week's Must Reads

Stroke Care Comparison of Asian Americans and Whites, JAMA Neurology; ePub 2019 Jan 22; Song, Liang, et al

Aerobic Exercise Can Improve Executive Functioning , Neurology; 2019 Jan 15; Blumenthal, et al

Episodic Memory Decline is Neurodegenerative Marker, Neurology; ePub 2019 Jan 23; Wilson, Yang, et al

Serum Troponin Level Marker for Visceral Infarcts , J Stroke Cerebrovasc Dis; ePub 2019 Jan 18; Azher, et al

Urine Sodium-to-Potassium Ratio Predicts Stroke, Stroke; ePub 2019 Jan 21; Averill, Young, et al

Must Reads in Multiple Sclerosis

Prevalence of Asthma in Persons with MS, Mult Scler Relat Disord; ePub 2018 Dec 11; Hill, et al

Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al

MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al