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Total Hip, Knee Arthroplasty in Patients with MS

Int J MS Care; 2018 Sep-Oct; Gutman, et al

Results of a recent study suggest that pain reduction is a realistic outcome of total knee or hip arthroplasty in people with multiple sclerosis (MS) and that improved functional gait outcomes are possible in some patients. Of 40 identified patients who underwent hip or knee replacement, 30 had sufficient data for inclusion in this study. Researchers reviewed their medical records and recorded reasons for surgery, age at surgery, MS characteristics, surgical complications, and ambulatory aid status before and after surgery. They supplemented medical record review with questionnaires regarding preoperative and postoperative pain and satisfaction with surgical outcomes. They found:

  • Median follow-up was 26 months.
  • Complications of surgery were reported in 10 patients (33%), mostly mild and self-limited, although 4 patients (13%) required repeated operation.
  • 6 patients (20%) reported improvements in ambulatory aid use compared with pre-surgery baseline, 10 (33%) worsened, and 14 (47%) were unchanged.
  • In 20 patients who completed the questionnaire, mean ± SD joint pain scores (on 0–10 scale) decreased from 8.6 ± 2.0 preoperatively to 2.9 ± 2.4 postoperatively.
  • 5 patients (25%) were free of joint pain at last follow-up.


Gutman JM, Kim K, Schwarzkopf R, Kister I. Total hip and knee arthroplasty in patients with multiple sclerosis. Int J MS Care. 2018;20(5):244-250. doi:10.7224/1537-2073.2017-093.