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Pregnancy Rates for Women with MS Increasing

Neurology; ePub 2018 Sep 28; Houtchens, et al

Pregnancy rates in women with multiple sclerosis (MS) have been increasing, according to a recent study. In addition, high rates of claims for several peripartum complications were observed in women with and those without MS. In a retrospective US administrative claims study, researchers used data from January 1, 2006, to June 30, 2015. All data for women with MS were included. A nationally representative 5% random sample from approximately 58 million women without MS was used to compute the dataset. They found:

  • From 2006 to 2014, the adjusted proportion of women with MS and pregnancy increased from 7.91% to 9.47%; the adjusted proportion without MS and with pregnancy decreased from 8.83% to 7.75%.
  • The difference in linear trend (0.17% increase and 0.15% decrease in per-annum pregnancy rates) was significant (t statistic = 7.8).
  • After matching (n=2,115 per group), a higher proportion of women with MS than without had claims for premature labor, infection, cardiovascular disease, anemia/acquired coagulation disorders, neurologic complications, sexually transmitted diseases, acquired fetal damage, and congenital fetal malformations.

Houtchens MK, Edwards NC, Schneider G, Stern K, Phillips AL. Pregnancy rates and outcomes in women with and without MS in the United States. [Published online ahead of print September 28, 2018]. Neurology. doi:10.1212/WNL.0000000000006384.