Functional activation may be useful as a predictive measure of episodic memory loss in patients with multiple sclerosis (MS), a recent study found. Researchers used functional magnetic resonance imaging (fMRI) during a verbal episodic memory task, lesion load, and volumetric measures of the hippocampus and thalamus to assess the relative contributions to verbal and visual-spatial episodic memory in persons with MS (n=32) and healthy controls (n=16). They found:
- After adjusting for disease duration, immediate recall performance on a visual-spatial episodic memory task was significantly predicted by hippocampal volume.
- Delayed recall on the same task was significantly predicted by volume of the left thalamus.
- For both memory measures, functional activation of the thalamus during encoding was more predictive than that of volume measures.
Koenig KA, Rao SM, Lowe MJ, et al. The role of the thalamus and hippocampus in episodic memory performance in patients with multiple sclerosis. [Published online ahead of print March 7, 2018]. Mult Scler. doi:10.1177/1352458518760716.
This Week's Must Reads
Hospital Readmission After Seizure Discharge, Neurology; ePub 2018 Dec 21; Blank, et al
VP Shunts and Post-Operative Complications Assessed, J Stroke Cerebrovasc Dis; ePub 2018 Dec 20; Linzey, et al
Disparities in Inter-Hospital Helicopter Transport, J Stroke Cerebrovasc Dis; ePub 2018 Dec 11; Sarrazin, et al
Mild-to-Moderate OSA Linked with Hypertension, Sleep; ePub 2018 Dec 22; Vgontzas, et al
Aspirin Reduces Stroke Risk in Women with Prior HDP, Neurology; ePub 2018 Dec 26; Miller, Boehme, et al
Must Reads in Multiple Sclerosis
Prevalence of Asthma in Persons with MS, Mult Scler Relat Disord; ePub 2018 Dec 11; Hill, et al
Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al
MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al
Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al
Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al