Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

No Link Between Overall Diet, MS Risk in Women

Mult Scler; ePub 2018 Oct 23; Rotstein, et al

There was no evidence of an association between overall diet quality and risk of developing multiple sclerosis (MS) among women, according to a recent study. >185,000 women in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII) completed semi-quantitative food frequency questionnaires every 4 years. There were 480 MS incident cases. Diet quality was assessed using the Alternative Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (aMED) index, and Dietary Approaches to Stop Hypertension (DASH) index. Researchers found:

  • None of the dietary indices, AHEI-2010, aMED, or DASH, at baseline was statistically significantly related to the risk of MS.
  • The principal component analysis identified “Western” and “prudent” dietary patterns, neither of which was associated with MS risk (HR, top vs bottom quintile: Western, 0.81 and prudent, 0.96).
  • When the analysis was repeated using cumulative average dietary pattern scores, the results were unchanged.


Rotstein DL, Cortese M, Fung TT, Chitnis T, Ascherio A, Munger KL. Diet quality and risk of multiple sclerosis in two cohorts of US women. [Published online ahead of print October 23, 2018]. Mult Scler. doi:10.1177%2F1352458518807061.

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Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al

MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al