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Neutrophil granulocyte markers may distinguish between demyelinating diseases

Key clinical point: Neutrophil granulocyte markers have high sensitivity and specificity for distinguishing acute NMOSD and MOGAD from relapsing-remitting MS.

Major finding: The area under the curve was 0.91 for elastase and neutrophil gelatinase-associated lipocalin, 0.82 for myeloperoxidase, and 0.81 for matrix metalloproteinase-8.

Study details: An evaluation of CSF from 42 patients with NMOSD, 6 with MOGAD, 41 with relapsing-remitting MS, and 25 healthy controls.

Disclosures: Dr. Leppert did not report any disclosures or outside funding. Dr. Weinshenker holds a patent on a diagnostic test for NMOSD and has received compensation for activities related to clinical trials in NMOSD.


Leppert D et al. MSVirtual2020. Abstract LB01.03.