Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Muscle Strength Key in Determining Gait Speed in MS

Mult Scler Relat Disord; ePub 2018 Oct 9; Yang, et al

Muscle strength, particularly the knee joint strength capacity, could be a principal factor determining gait speed in people with mild to moderate multiple sclerosis (MS), a recent study found. 31 individuals with MS (the mean [standard deviation] of the Patient Determined Disability Steps: 3.68[1.70]) participated in this cross-sectional observational study. Their gait speed was assessed using the Timed-25-Foot Walking test. 6 factors which could slow gait speed in MS, including the strength capacity at knee joints, functional mobility, body balance, dorsiflexion range of motion of ankle joints, bilateral foot cutaneous sensation level, and the fear of falling, were also assessed. Multiple regression and relative weight analysis were used to identify the relative importance of each factor in explaining the gait speed variation. Researchers found:

  • All 6 factors together accounted for about 86% of the observed variation in gait speed; each explaining a statistically significant amount.
  • The most important factor was the strength measurement (relative weight = 0.321) which accounted for 37.2% of the explained variation in gait speed.


Yang F, Qiao M, Su X, Lazarus J. Relative importance of physical and psychological factors to slowness in people with mild to moderate multiple sclerosis. [Published online ahead of print October 9, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.10.005.