Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Internet-Based Intervention for Physical Activity

Mult Scler J Exp Transl Clin; 2017 Oct 9; Motl, et al

A recent study has illustrated the efficacy of an Internet-based behavioral intervention with content delivered through interactive video courses grounded in e-learning principles for increasing physical activity and possibly improving secondary outcomes of fatigue, depression, anxiety, and walking impairment/disability in persons with multiple sclerosis (MS). Participants with MS (n=47) were randomly assigned into behavioral intervention (n=23) or waitlist control (n=24) conditions delivered over a 6-month period. Outcomes were administered before and after the 6-month period using blinded assessors, and data were analyzed. Researchers found:

  • There was a significant, positive intervention effect on self-reported physical activity, and non-significant improvement in objectively measured physical activity.
  • There were significant, positive effects of the intervention on overall and physical impact of fatigue, self-reported walking impairment, and disability status.
  • There were non-significant improvements in fatigue severity, depression and anxiety symptoms, and self-reported disability.


Motl RW, Hubbard EA, Bollaert RE, et al. Randomized controlled trial of an e-learning designed behavioral intervention for increasing physical activity behavior in multiple sclerosis. Mult Scler J Exp Transl Clin. 2017;3(4):2055217317734886. doi:10.1177/2055217317734886.