Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Criterion Based on the Central Vein Sign Distinguishes Between MS and Mimics

Key clinical point: Applying a criterion of three lesions with the central vein sign distinguishes between multiple sclerosis and its mimics.

Major finding: The criterion has a sensitivity and specificity of 61.9% and 89.0%, respectively.

Study details: A multicenter study of 606 participants with clinically isolated syndrome, multiple sclerosis, and multiple sclerosis mimics.

Disclosures: Dr. Sinnecker reported receiving personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Actelion.


Sinnecker T et al. AAN 2019, Abstract S6.002.