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Cerebellum and Cognition Assessed in Progressive MS

J Neurology; ePub 2018 Jul 28; Cocozza, et al

Patients with progressive multiple sclerosis (PMS) show cerebellar functional connectivity (FC) rearrangements that are partially independent from cerebellar structural damage, and are likely expression of a maladaptive functional rewiring. This according to a recent study that aimed to investigate lobular cerebellar FC in patients with PMS in relation to cognition. In this cross-sectional study, resting state fMRI analysis was carried out on 29 PMS patients and 22 age- and sex-matched healthy controls (HC). Data were analyzed with a seed-based approach, with 4 different seeds placed at the level of cerebellar Lobule VI, Crus I, Crus II, and Lobule VIIb, accounting for cerebellar structural damage. Researchers found:

  • When testing FC differences between PMS and HC without taking into account cerebellar structural damage, PMS patients showed a reduction of FC between Crus II/Lobule VIIb and the right frontal pole, with an increased FC between Lobule VIIb and the right precentral gyrus.
  • After controlling for structural damage, PMS patients still showed a reduced FC between Crus II and right frontal pole, as well as an increased FC between Lobule VIIb and right precentral gyrus.

Citation:

Cocozza S, Pontillo G, Russo C, et al. Cerebellum and cognition in progressive MS patients: functional changes beyond atrophy? [Published online ahead of print July 28, 2018]. J Neurology. doi:10.1007/s00415-018-8985-6.

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