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Supranuclear Gaze Palsy Not Diagnostic for PSP

Parkinsonism Relat Disord; ePub 2017 Feb 23; Martin, et al

Although a common feature of progressive supranuclear palsy (PSP), supranuclear gaze palsy (SGP) is not diagnostic for this condition and can be associated with other neurodegenerative causes of parkinsonism, including Parkinson disease (PD). Researchers reviewed clinical and autopsy data maintained in an electronic medical record from all patients seen in the Movement Disorders Clinic at Washington University, St. Louis, between 1996 and 2015. All patients with parkinsonism from this population who had subsequent autopsy confirmation of diagnosis underwent further analysis. They found:

  • 221 unique parkinsonian patients had autopsy-proven diagnoses, 27 of whom had SGP documented at some point during their illness.
  • Major diagnoses associated with SGP were: PSP (9 patients), PD (10 patients), multiple system atrophy (2 patients), corticobasal degeneration (2 patients), Creutzfeldt-Jakob disease (1 patient), and Huntington disease (1 patient).
  • In none of the diagnostic groups was the age of onset or disease duration significantly different between cases with SGP and those without SGP.

Citation:

Martin WRW, Hartlein J, Racette BA, Cairns N, Perlmutter JS. Pathologic correlates of supranuclear gaze palsy with parkinsonism. [Published online ahead of print February 23, 2017]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2017.02.027.