Clinical Edge

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Researchers identify a cause of L-DOPA–induced dyskinesia in Parkinson’s disease

Key clinical point: Understanding the chemical responsible for treatment-related dyskinesia may help improve therapy for Parkinson’s disease.

Major finding: RasGRP1 directs the development of L-DOPA–induced dyskinesia in Parkinson’s disease.

Study details: A prospective study of 55 mouse models of Parkinson’s disease.

Disclosures: The study was supported by grants from the National Institutes of Health. The authors reported no conflicts of interest.


Eshraghi M et al. Sci Adv. 2020;6:eaaz7001.