Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

PD Global Burden More than Doubles, from 1990-2016

Lancet Neurol; ePub 2018 Oct 1; Dorsey, et al

During the past generation, the global burden of Parkinson disease (PD) has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. This according to a study that aimed to determine the global burden of PD between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Furthermore, demographic and potential other factors are poised to increase the future burden of PD substantially. Through a systematic analysis of epidemiological studies, researchers estimated global, regional, and country-specific prevalence, and years of life lived with disability from PD from 1990 to 2016. They found:

  • In 2016, 6.1 million individuals had PD globally, compared with 2.5 million in 1990.
  • This increase was not solely due to increasing numbers of older people, because age-standardized prevalence rates increased by 21.7% during the same period (compared with an increase of 74.3%, for crude prevalence rates).
  • PD caused 3.2 million disability-adjusted life-years (DALYs) and 211,296 deaths in 2016.
  • The male-to-female ratios of age-standardized prevalence rates were similar in 2016 (1.40) and 1990 (1.37).


Dorsey ER, Elbaz A, Nichols E, et al, as part of GBD 2016 Parkinson’s Disease Collaborators. Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. [Published online ahead of print October 1, 2018]. Lancet Neurol. doi:10.1016/S1474-4422(18)30295-3.

This Week's Must Reads

Stroke Care Comparison of Asian Americans and Whites, JAMA Neurology; ePub 2019 Jan 22; Song, Liang, et al

Aerobic Exercise Can Improve Executive Functioning , Neurology; 2019 Jan 15; Blumenthal, et al

Episodic Memory Decline is Neurodegenerative Marker, Neurology; ePub 2019 Jan 23; Wilson, Yang, et al

Serum Troponin Level Marker for Visceral Infarcts , J Stroke Cerebrovasc Dis; ePub 2019 Jan 18; Azher, et al

Urine Sodium-to-Potassium Ratio Predicts Stroke, Stroke; ePub 2019 Jan 21; Averill, Young, et al

Must Reads in Movement Disorders

Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al