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PD Global Burden More than Doubles, from 1990-2016

Lancet Neurol; ePub 2018 Oct 1; Dorsey, et al

During the past generation, the global burden of Parkinson disease (PD) has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. This according to a study that aimed to determine the global burden of PD between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Furthermore, demographic and potential other factors are poised to increase the future burden of PD substantially. Through a systematic analysis of epidemiological studies, researchers estimated global, regional, and country-specific prevalence, and years of life lived with disability from PD from 1990 to 2016. They found:

  • In 2016, 6.1 million individuals had PD globally, compared with 2.5 million in 1990.
  • This increase was not solely due to increasing numbers of older people, because age-standardized prevalence rates increased by 21.7% during the same period (compared with an increase of 74.3%, for crude prevalence rates).
  • PD caused 3.2 million disability-adjusted life-years (DALYs) and 211,296 deaths in 2016.
  • The male-to-female ratios of age-standardized prevalence rates were similar in 2016 (1.40) and 1990 (1.37).


Dorsey ER, Elbaz A, Nichols E, et al, as part of GBD 2016 Parkinson’s Disease Collaborators. Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. [Published online ahead of print October 1, 2018]. Lancet Neurol. doi:10.1016/S1474-4422(18)30295-3.