Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

MRI-Guided Thalamotomy Presents New Option for ET

Mov Disord; ePub 2018 Apr 27; Fishman, et al

The overall safety profile of magnetic resonance imaging-guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor (ET), a recent study found. Researchers sought to determine the safety profile of magnetic resonance imaging-guided focused ultrasound unilateral thalamotomy for ET, including frequency, and severity of adverse events, including serious adverse events. 186 patients and 5 studies were included in an analysis of safety data. They found:

  • Procedure‐related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections.
  • Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%).
  • As previously reported, abnormalities in sensation and balance were the commonest thalamotomy‐related adverse events.
Citation:

Fishman PS, Elias WJ, Ghanouni P, et al. Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor. [Published online ahead of print April 27, 2018]. Mov Disord. doi:10.1002/mds.27401.

Must Reads in Movement Disorders

Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al