Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

MRI-Guided Thalamotomy Presents New Option for ET

Mov Disord; ePub 2018 Apr 27; Fishman, et al

The overall safety profile of magnetic resonance imaging-guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor (ET), a recent study found. Researchers sought to determine the safety profile of magnetic resonance imaging-guided focused ultrasound unilateral thalamotomy for ET, including frequency, and severity of adverse events, including serious adverse events. 186 patients and 5 studies were included in an analysis of safety data. They found:

  • Procedure‐related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections.
  • Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%).
  • As previously reported, abnormalities in sensation and balance were the commonest thalamotomy‐related adverse events.

Fishman PS, Elias WJ, Ghanouni P, et al. Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor. [Published online ahead of print April 27, 2018]. Mov Disord. doi:10.1002/mds.27401.

Must Reads in Movement Disorders

Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al