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Mild Cognitive Impairment in Essential Tremor

J Int Neuropsychol Soc; ePub 2018 Oct 10; Cersonsky, et al

Mild cognitive difficulty among essential tremor (ET) subjects is best predicted by combined performance on 5 measures of memory and executive function, a recent study found. These results inform the nature of cognitive dysfunction in ET and the creation of a brief cognitive battery to assess patients with ET for cognitively driven dysfunction in life that could indicate the presence of mild cognitive impairment (MCI). A total of 196 ET subjects enrolled in a prospective, longitudinal, clinical-pathological study underwent an extensive motor-free neuropsychological test battery and were assigned a Clinical Dementia Rating (CDR) score. Logistic regression analyses were performed to identify the neuropsychological tests which best identified individuals with CDR of 0.5 (mild deficits in cognition) vs 0 (normal cognition). Researchers found:

  • In regression models, 5 tests in the domains of Memory and Executive Function were identified that best discriminated subjects with CDR of 0.5 vs 0 (86.9% model classification accuracy).
  • These tests were the California Verbal Learning Test II Total Recall, Logical Memory II, Verbal-Paired Associates I, Category Switching Fluency, and Color-Word Inhibition.


Cersonsky TEK, Morgan S, Kellner S, et al. Evaluating mild cognitive impairment in essential tremor: How many and which neuropsychological tests? [Published online ahead of print October 10, 2018]. J Int Neuropsychol Soc. doi:10.1017/S1355617718000747.