Key clinical point: Early measures of neurodegeneration appeared approximately 24 years from predicted clinical onset of Huntington’s disease.
Major finding: The CSF neurofilament light protein (NfL), was associated with predicted years to the onset of Huntington’s disease in genetic carriers; 53% of individuals with pre-Huntington’s had CSF NfL values in the normal range and 47% had elevated values compared with controls.
Study details: The data come from the Huntington’s disease Young Adult Study (HD-YAS) conducted in the United Kingdom and included 64 young adults with Huntington’s disease and 67 controls.
Disclosures: The study was supported by the Wellcome Trust, CHDI Foundation. The researchers had no financial conflicts to disclose.