Clinical Edge

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Estrogen Exposure May Provide Protection from PSP

Mov Disord; ePub 2018 Feb 20; Park, Ilango, et al

A recent case-control study suggests a protective role of lifetime estrogen exposure in progressive supranuclear palsy (PSP). Researchers evaluated the self-reported reproductive characteristics and estrogen of 150 women with PSP and 150 age-matched female controls who participated in the Environmental Genetic-PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen. They found:

  • There was no association between years of estrogen exposure duration and PSP.
  • There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance.
  • Any exposure to estrogen replacement therapy halved the risk of PSP.
  • Among PSP cases, earlier age at menarche was associated with better performance on Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale II score at clinical examination.

Park HK, Ilango S, Charriez CM, et al. Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study. [Published online ahead of print February 20, 2018]. Mov Disord. doi:10.1002/mds.27336.