The presence of cerebellar signs did not aggregate in families with essential tremor (ET), a recent study found. In the current dataset, these did not seem to be disease features that were heritable. 187 ET subjects (59 probands, 128 affected relatives) enrolled in a genetic study at Yale and Columbia universities underwent a detailed videotaped neurological examination. Researchers found:
- In a bivariate logistic regression model, the presence of intention tremor in the proband was not a predictor of the presence of intention tremor in the relatives.
- In a similar model, the presence of greater tandem gait difficulty (ie, a tandem gait score in the upper quartile) in the proband was not a predictor of the presence of such difficulty in the relatives.
Louis ED, Hernandez N, Chen KP, et al. Familial aggregation of the cerebellar signs in familial essential tremor. [Published online ahead of print January 13, 2017]. Tremor Other Hyperkinet Mov. doi:10.7916/D8KK9C8Q.
This Week's Must Reads
Must Reads in Movement Disorders
Risk Factors for Suicidality in Huntington Disease, Neurology; ePub 2019 Mar 8; McGarry, et al
Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al
Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al
White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al