Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Appendectomy and Risk of Parkinson Disease

Mov Disord; ePub 2018 Sep 14; Palacios, et al

There is limited to no association between appendectomy and Parkinson disease (PD) risk, according to a recent study. Researchers examined whether history of self‐reported appendectomy was related to risk of incident PD in the Nurses’ Health Study and the Health Professionals Follow‐up Study. They used the Cox proportional hazards model to estimate the hazard ratio (HR) of PD associated with self‐report of appendectomy in men and women. Among women, they estimated the HR of PD associated with appendectomy for appendicitis and incidental appendectomy. They found:

  • In pooled analyses, self‐report of any appendectomy was not related to PD risk: the HR of PD comparing participants who reported any appendectomy with those who did not was 1.08.
  • In women, appendectomy for appendicitis, but not incidental appendectomy, was associated with a modestly elevated risk of PD (HR, 1.23).


Palacios N, Hughes KC, Cereda E, Schwarzschild MA, Ascherio A. Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women. [Published online ahead of print September 14, 2018]. Mov Disord. doi:10.1002/mds.109.