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Tourette, CTD, and Cardiometabolic Disorders Link

JAMA Neurology; ePub 2018 Jan 14; Brander, et al

The findings of a recent, longitudinal, population-based, cohort study suggest that Tourette syndrome (TS) and chronic tic disorder (CTD) are associated with a substantial risk of metabolic and cardiovascular (CV) disorders. Therefore, these results highlight the importance of carefully monitoring cardiometabolic health in patients with TS or CTD across the lifespan, particularly in those with comorbid attention-deficit/hyperactivity disorder. Data analyses were conducted from August 1, 2017, to October 11, 2018. Researchers found:

  • Of 14,045,026 individuals in the cohort, 7,804 (5,964 males [76.4%]; median age at first diagnosis, 13.3 years) had a registered diagnosis of TS or CTD in specialist care.
  • Of 2,675,482 families with at least 2 singleton full siblings, 5,141 families included siblings who were discordant for these disorders.
  • Individuals with TS or CTD had a higher risk of any metabolic or CV disorders compared with the general population and sibling controls.
  • Specifically, individuals with TS or CTD had higher risks for obesity, type 2 diabetes, and circulatory system diseases.
  • The risk of any cardiometabolic disorder was significantly greater in males than in females, as was the risk of obesity.

Brander G, Isomura K, Chang Z, et al. Association of Tourette syndrome and chronic tic disorder with metabolic and cardiovascular disorders. [Published online ahead of print January 14, 2019]. JAMA Neurology. doi:10.1001/jamaneurol.2018.4279.