Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Tourette, CTD, and Cardiometabolic Disorders Link

JAMA Neurology; ePub 2018 Jan 14; Brander, et al

The findings of a recent, longitudinal, population-based, cohort study suggest that Tourette syndrome (TS) and chronic tic disorder (CTD) are associated with a substantial risk of metabolic and cardiovascular (CV) disorders. Therefore, these results highlight the importance of carefully monitoring cardiometabolic health in patients with TS or CTD across the lifespan, particularly in those with comorbid attention-deficit/hyperactivity disorder. Data analyses were conducted from August 1, 2017, to October 11, 2018. Researchers found:

  • Of 14,045,026 individuals in the cohort, 7,804 (5,964 males [76.4%]; median age at first diagnosis, 13.3 years) had a registered diagnosis of TS or CTD in specialist care.
  • Of 2,675,482 families with at least 2 singleton full siblings, 5,141 families included siblings who were discordant for these disorders.
  • Individuals with TS or CTD had a higher risk of any metabolic or CV disorders compared with the general population and sibling controls.
  • Specifically, individuals with TS or CTD had higher risks for obesity, type 2 diabetes, and circulatory system diseases.
  • The risk of any cardiometabolic disorder was significantly greater in males than in females, as was the risk of obesity.
Citation:

Brander G, Isomura K, Chang Z, et al. Association of Tourette syndrome and chronic tic disorder with metabolic and cardiovascular disorders. [Published online ahead of print January 14, 2019]. JAMA Neurology. doi:10.1001/jamaneurol.2018.4279.

This Week's Must Reads

Risk Factors for Suicidality in Huntington Disease, Neurology; ePub 2019 Mar 8; McGarry, et al

Socioeconomic Disparities in US Stroke Survivors, Stroke; ePub 2019 Mar 11; Elfassy, Grasset, et al

Treating Stroke Patients with tPA via Telemedicine, Stroke; ePub 2019 Mar 11; Wysocki, et al

Can a Modified Ketogenic Diet Reduce Seizures?, Epilepsy Behav; ePub 2019 Mar 10; Roehl, et al

No Association Between Self-Reported TBI and AD, Alzheimers Dement; ePub 2019 Mar 6; Sugarman, et al

Must Reads in Mixed Topics

Risk Factors for Suicidality in Huntington Disease, Neurology; ePub 2019 Mar 8; McGarry, et al

Global Burden of Brain and Other CNS Cancers, Lancet Neurol; ePub 2019 Feb 20; GBD 2016 Brain and Other CNS Cancer Collaborators

Genetic Basis of Motoric Cognitive Risk Syndrome, Neurology; ePub 2019 Feb 8; Sathyan, et al

Blood Pressure and WM Hyperintensity Progression, Neurology; ePub 2019 Feb 8; de Havenon, et al

Hearing Loss Linked Cognitive Decline Risk in Men, Alzheimers Dement; ePub 2019 Jan 29; Curhan, et al