Sickle cell trait (SCT) may not be associated with incidence of ischemic stroke among African American, according to a recent meta-analysis that suggests performing a more thorough clinical evaluation of a stroke patient with SCT rather than assuming that SCT is the etiologic factor for the stroke. This meta-analysis included 19,464 African American individuals (1,520 with SCT, 17,944 without SCT, and 620 with ischemic stroke) from 4 studies, with a mean (SD) age of 60.0 (13.0) years, (5,257 [27.0%] men and 14,207 [73.0%] women). Researchers found:
- No differences were found in the distribution of risk factors for ischemic stroke comparing participants with and those without SCT at study visit 1 in each cohort.
- The crude incidence of ischemic stroke was 2.9 per 1,000 person-years among those with SCT and 3.2 per 1,000 person-years among those without SCT.
- After stroke risk factors were adjusted for, the hazard ratio of incident ischemic stroke independently associated with SCT in the meta-analysis of all 4 cohorts was 0.80.
- The results of the meta-analysis were similar to those of individual cohorts, in which the results were also similar.
Hyacinth HI, Carty CL, Seals SR, et al. Association of sickle cell trait with ischemic stroke among African Americans. A meta-analysis. [Published online ahead of print April 23, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.0571.