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Gout Linked with 2-Fold Higher Risk of Sleep Apnea

J Clin Sleep Med; ePub 2018 Aug 30; Singh, Cleveland

The independent association of gout with a 2-fold higher risk of obstructive sleep apnea (OSA) in older adults indicates that common mechanisms may be shared by the 2 conditions, according to a recent study. Researchers used the 5% US Medicare beneficiary sample from 2006–2012 to assess whether gout was independently associated with new diagnosis of OSA in adults aged ≥65 years, adjusting for demographics, medical comorbidity (Charlson-Romano index) and hypertension, hyperlipidemia and coronary artery disease, and the use of medications for cardiovascular diseases or gout. They found:

  • Based on 10,448,472 person-years of follow-up in a cohort of 1.74 million adults aged ≥65 years, the crude incidence rates of OSA were 14.3 per 1,000 person-years in people with gout and 3.9 per 1,000 person-years in people without gout.
  • In multivariable-adjusted analyses, gout was associated with higher risk of a new diagnosis of OSA during the follow-up (hazard ratio (HR) was 2.07).
  • In sensitivity analyses that substituted continuous Charlson-Romano score with a categorical variable or individual Charlson-Romano comorbidities plus hypertension, hyperlipidemia, and coronary artery disease, the main finding was confirmed (HRs were 2.11 and 1.79).


Singh JA, Cleveland JD. Gout and the risk of incident obstructive sleep apnea in adults 65 years or older: An observational study. [Published online ahead of print August 30, 2018]. J Clin Sleep Med. doi:10.5664/jcsm.7328.