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Global Burden of Brain and Other CNS Cancers

Lancet Neurol; ePub 2019 Feb 20; GBD 2016 Brain and Other CNS Cancer Collaborators

Central nervous system (CNS) cancer is responsible for substantial morbidity and mortality worldwide, and incidence increased between 1990 and 2016, according to data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016. In 2016, there were 330,000 incident cases of CNS cancer and 227,000 deaths globally, and age-standardized incidence rates of CNS cancer increased globally by 17.3% between 1990 and 2016 (2016 age-standardized incidence rate 4.63 per 100,000 person-years). Key highlights of the investigation include:

  • The top 3 countries with the highest number of incident cases were China, US, and India.
  • The highest age-standardized incidence rate was in the highest quintile of SDI (6.91).
  • Age-standardized incidence rates increased with each socio-demographic index (SDI) quintile.
  • East Asia was the region with the most incident cases of CNS cancer for both sexes in 2016 (108,000), followed by western Europe (49,000), and south Asia (31,000).
  • CNS cancer was responsible for 7.7 million disability-adjusted life-years (DALYs) globally, a non-significant change in age-standardized DALY rate of −10.0% between 1990 and 2016.

GBD 2016 Brain and Other CNS Cancer Collaborators. Global, regional, and national burden of brain and other CNS cancer, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. [Published online ahead of print February 20, 2019]. Lancet Neurol. doi:10.1016/S1474-4422(18)30468-X.