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Aspirin Reduces Stroke Risk in Women with Prior HDP

Neurology; ePub 2018 Dec 26; Miller, Boehme, et al

After controlling for comorbid conditions, women with prior hypertensive disorders of pregnancy (HDP) had increased long-term stroke risk, which was reduced by aspirin use, a recent study found. California Teachers Study (CTS) participants aged ≤60 years at the time of enrollment in 1995 were followed up prospectively for validated stroke outcomes obtained via linkage with California hospital records through December 31, 2015. Researchers calculated unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the primary outcomes of all stroke and stroke before age 60 among those with and without a history of HDP. They found:

  • Of 83,749 women included in the analysis, 4,070 (4.9%) had HDP.
  • Women with prior HDP had increased risk of all stroke (adjusted HR 1.3) but no increased risk of stroke before age 60 (adjusted HR 1.2).
  • There was an interaction between aspirin use and HDP history on risk of stroke before age 60: nonusers of aspirin had higher risk (adjusted HR 1.5) while aspirin users did not (adjusted HR 0.8).


Miller EC, Boehme AK, Chung NT, et al. Aspirin reduces long-term stroke risk in women with prior hypertensive disorders of pregnancy. [Published online ahead of print December 26, 2018]. Neurology. doi:10.1212/WNL.0000000000006815.