Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

BP levels during endovascular stroke therapy affect neurologic outcomes

Key clinical point: Prolonged durations of mean arterial blood pressure above or below certain thresholds during endovascular therapy may be linked to poor functional outcomes in patients with acute ischemic stroke.

Major finding: Mean arterial blood pressure below 70 mm Hg for 10 minutes or more, or above 90 mm Hg for 45 minutes or more, was associated with increased odds of higher 90-day modified Rankin scale scores and a number needed to harm of 10.

Study details: A retrospective analysis of 365 patients from three randomized clinical trials.

Disclosures: The study authors reported receiving grant support from the Health Research Foundation of Central Denmark Region, the Danish National Helicopter Emergency Medical Service Foundation, and the Novo Nordisk Foundation; a research award from the Patient-Centered Outcomes Research Institute; and personal fees from Abbott Medical Sweden, I4L Innovation for Life, Boehringer Ingelheim, Medtronic, and Zoll.


Rasmussen M et al. JAMA Neurol. 2020 Jan 27. doi: 10.1001/jamaneurol.2019.4838.