Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antibiotic use may increase the risk of Parkinson’s disease

Key clinical point: Use of certain antimicrobials may be associated with the development of Parkinson’s disease.

Major finding: Use of tetracyclines was associated with a significantly increased risk of Parkinson’s disease 10-15 years later.

Study details: A nationwide case-control study in 13,976 individuals with Parkinson’s disease and 40,697 controls.

Disclosures: The study was funded by the Finnish Parkinson Foundation, the Finnish Medical Foundation, the Maire Taponen Foundation, and the Academy of Finland. One author declared relevant patents and his position as founder and chief executive of a private company. No other conflicts of interest were declared.


Mertsalmi TH et al. Mov Disord. 2019 Nov 18. doi: 10.1002/mds.27924.