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Vasomotor Symptoms in Perimenopausal Migraine

A history of migraine predicts an increased frequency of vasomotor symptoms (VMS) in women during menopausal transition, a new study found. The study sample consisted of 467 women with a self-reported prior migraine diagnosis and 2,466 women without prior migraine diagnosis who were assessed longitudinally during menopausal transitions as part of the Study of Women’s Health Across the Nation. Linear mixed regression models with backward elimination were used to evaluate longitudinal associations between VMS and migraine while adjusting for baseline and time-varying demographic, socioeconomic, psychological, and reproductive factors. Researchers found:

  • A history of migraine predicted an increased frequency of VMS but not vaginal dryness during menopausal transition.
  • Significant interaction between history of migraine and menopausal status for the prediction of VMS was also identified.
  • Burden of VMS was higher during late perimenopause state in women with migraine.


Maleki N, Cheng Y-C, Tu Y, Locascio JJ. Longitudinal course of vasomotor symptoms in perimenopausal migraineurs. [Published online ahead of print April 2, 2019]. Ann Neurol. doi:10.1002/ana.25476.