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Risk of Ischemic Stroke in Patients with Migraine

Migraine is associated with an increased risk of ischemic stroke, but not hemorrhagic stroke, a new study found. The longitudinal follow-up study included data from a national cohort between 2002 and 2013. Researchers extracted data from patients with migraine (n=41,585) and 1:4 matched controls (n=166,340) and analyzed the occurrence of ischemic and hemorrhagic stroke. The migraine group included participants treated for migraine ≥2 times. Researchers found:

  • Higher rates of ischemic stroke were observed in the migraine group vs the control group (2.3% vs 2.0%).
  • The adjusted hazard ratio of ischemic stroke was 1.18 in the migraine group.
  • Compared with controls, participants who reported migraine with aura and migraine without aura had increased adjusted HRs of 1.44 and 1.15, respectively, for ischemic stroke, but no increased risk of hemorrhagic stroke.
  • In subgroup analysis, there was a strong association between migraine and ischemic stroke in young patients, especially young women.


Lee SY, Lim JS, Oh DJ, Kong JG, Choi HG. Risk of ischemic stroke in patients with migraine: A longitudinal follow-up study using a national sample cohort in South Korea. [Published online ahead of print April 2, 2019]. BMJ Open. doi:10.1136/bmjopen-2018-027701.