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Migraine & Risks of Adverse Pregnancy Outcomes

Women with migraine and their offspring have greater risks of adverse pregnancy outcomes than women without migraine, a new study found. Researchers investigated the associations between maternal migraine and risks of adverse pregnancy outcomes in the mother, and birth, neonatal and postnatal outcomes in the offspring. They evaluated a cohort of pregnancies among women with migraine and an age- and conception year-matched comparison cohort of pregnancies among women without migraine. They found:

  • 22,841 pregnancies among women with migraine and 228,324 matched pregnancies among women without pregnancies were identified.
  • Migraine was associated with an increased risk of pregnancy-associated hypertension disorders and miscarriage.
  • Migraine was also associated with an increased prevalence of low birth weight, preterm birth, and cesarean delivery, but not of small for gestational age offspring and birth defects.
  • Offspring prenatally exposed to maternal migraine had elevated risk of several outcomes in the neonatal and postnatal period.


Skajaa N, et al. Pregnancy, birth, neonatal, and postnatal neurological outcomes after pregnancy with migraine. [Published online ahead of print May 8, 2019]. Headache. doi:10.1111/head.13536.