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Migraine & Risks of Adverse Pregnancy Outcomes

Women with migraine and their offspring have greater risks of adverse pregnancy outcomes than women without migraine, a new study found. Researchers investigated the associations between maternal migraine and risks of adverse pregnancy outcomes in the mother, and birth, neonatal and postnatal outcomes in the offspring. They evaluated a cohort of pregnancies among women with migraine and an age- and conception year-matched comparison cohort of pregnancies among women without migraine. They found:

  • 22,841 pregnancies among women with migraine and 228,324 matched pregnancies among women without pregnancies were identified.
  • Migraine was associated with an increased risk of pregnancy-associated hypertension disorders and miscarriage.
  • Migraine was also associated with an increased prevalence of low birth weight, preterm birth, and cesarean delivery, but not of small for gestational age offspring and birth defects.
  • Offspring prenatally exposed to maternal migraine had elevated risk of several outcomes in the neonatal and postnatal period.

Citation:

Skajaa N, et al. Pregnancy, birth, neonatal, and postnatal neurological outcomes after pregnancy with migraine. [Published online ahead of print May 8, 2019]. Headache. doi:10.1111/head.13536.