Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Migraine as a Comorbidity of Functional Dyspepsia

In patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. 60 patients affected by functional dyspepsia, 38 with postprandial distress syndrome, and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated. Researchers found:

  • In epigastric pain syndrome, 54% of patients suffered from migraine and this condition was never correlated with meal ingestion.
  • In postprandial distress syndrome patients, 76% suffered from migraine, in 89% its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold.
  • In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine.


Di Stefano M, et al. Prevalence and pathophysiology of post-prandial migraine in patients with functional dyspepsia. [Published online ahead of print June 15, 2019]. Cephalalgia. doi: 10.1177/0333102419857596.