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Migraine and Cluster Headache and Neurosteroid Levels

Large and disease-specific changes in circulating neurosteroid levels are associated with chronic headache disorders, a new study found. 19 female patients affected by episodic migraine, 51 female patients affected by chronic migraine, and 18 males patients affected by cluster headache were included. Sex- and age-matched healthy control subjects were also recruited. Researchers found:

  • Disease-specific changes in neurosteroid levels were observed in the study groups.
  • Allopreganolone levels were significantly increased in episodic migraine and chronic migraine patients compared with control subjects, whereas they were reduced in patients affected by cluster headache.
  • Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels were reduced in patients affected by chronic migraine, but did not change in those affected by cluster headache.

Citation:

Koverech A, et al. Migraine and cluster headache show impaired neurosteroids patterns. [Published online ahead of print May 27, 2019]. J Headache Pain. doi: 10.1186/s10194-019-1005-0.