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Migraine in Adults with Atrial Septal Defect

Migraine and use of prescription migraine medication increased in adults with atrial septal defect (ASD), a new study found. The nationwide cohort study identified all patients born before 1994 diagnosed with ASD between 1959 and 2013 and included 2,277 patients and a gender and age matched comparison cohort of 22,756. Among the details:

  • Plasma serotonin was measured in 136 patients with a small, unclosed, ASDs and 18 controls.
  • Patients with ASD had an increased risk of receiving a migraine diagnosis and receiving migraine medication.
  • 10 years after closure, 93% of those using migraine medication preclosure were still receiving this.
  • Plasma serotonin was severely elevated in 18% of the patients with ASD.


Nyboe C, et al. The burden of migraine in adults with atrial septal defect: A nationwide cohort study. [Published online ahead of print May 15, 2019]. Sci Rep. doi: 10.1038/s41598-019-43895-z.