Most recent headache studies comply with the National Institute of Health (NIH) mandate to include women and minorities in research trials, particularly US-based and industry-funded studies, according to a recent study. Whites, however, are overrepresented compared to both the general population and the population of migraineurs. Researchers conducted a literature search for pertinent articles examining the inclusion of women and minorities in migraine clinical research trials. They identified controlled-trials for migraine published since 2011 in major neurology, headache, and general medicine journals using the term “migraine randomized controlled trial.” They found:
- 128 relevant clinical trials were identified, of which 36 met inclusion criteria.
- All 36 trials (100%) reported gender frequency, and 25 of 36 (69.4%) reported ethnicity or race.
- Among all studies, women and whites represented 84.2 and 82.9% of participants (mean), respectively.
- Men and non-whites in the US were statistically underrepresented.
Robbins NM, Bernat JL. Minority representation in migraine treatment trials. [Published online ahead of print January 27, 2017]. Headache. doi:10.1111/head.13018.