Clinical Edge

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Dosing Options in Migraine Prevention

Patients with migraine are more likely to fill a new prescription and adhere to a new therapy when their preferred dosing regimen is available, a new study found. Researchers evaluated the impact of having flexible dosing options on acceptance of and adherence to a new migraine preventive therapy class among adults with migraine. In this observational study, 2 online surveys were completed: one by physicians currently treating adult patients with migraine and the other by adults with migraine. Both surveys presented the participants with 2 scenarios: only monthly, only quarterly. Both dosing options of the new medication are available. Among the findings:

  • 400 physicians and 417 US adults with migraine completed the surveys.
  • The availability of both dosing options yielded a significant increase in the proportion of patients expected to receive the new medication.
  • The overall proportion of patients favoring monthly dosing (35%) was similar to the proportion favoring quarterly dosing (40%).


Cowan R, et al. Physician and patient preferences for dosing options in migraine prevention. [Published online ahead of print May 9, 2019]. J Headache Pain. doi:10.1186/s10194-019-0998-8.