Key clinical point: Patients with focal epilepsy have cortical thinning greater than that associated with normal aging.
Major finding: The mean annualized rate of global cortical thinning was 0.024 in patients with epilepsy and 0.011 in healthy volunteers.
Study details: A longitudinal study of MRI scans for 190 patients with focal epilepsy and 141 healthy controls.
Disclosures: The study and the authors received support from the Medical Research Council, the Wellcome Trust, and the University College London Hospital.
Galovic M et al. JAMA Neurol. 2019 Jul 1. doi: 10.1001/jamaneurol.2019.1708.