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Patients With Focal Epilepsy Have Progressive Cortical Thinning

Key clinical point: Patients with focal epilepsy have cortical thinning greater than that associated with normal aging.

Major finding: The mean annualized rate of global cortical thinning was 0.024 in patients with epilepsy and 0.011 in healthy volunteers.

Study details: A longitudinal study of MRI scans for 190 patients with focal epilepsy and 141 healthy controls.

Disclosures: The study and the authors received support from the Medical Research Council, the Wellcome Trust, and the University College London Hospital.


Galovic M et al. JAMA Neurol. 2019 Jul 1. doi: 10.1001/jamaneurol.2019.1708.