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Moderate Coffee Intake Associated With Few Seizures in Drug-Refractory Patients With Epilepsy

Key clinical point: The effect of caffeine on seizures may be dose dependent, with moderate doses potentially benefiting patients with epilepsy and high doses – four cups of coffee per day or more – potentially increasing seizure susceptibility.

Major finding: Patients with moderate coffee consumption were more likely to not have any secondary generalized tonic-clonic seizures (73.4%), compared with patients with no coffee consumption (64.4%), rare consumption (61.7%), and high consumption (56%).

Study details: A cross-sectional study of 620 adults with drug-resistant epilepsy.

Disclosures: The study was funded by the French Ministry of Health.


Bourgeois-Vionnet J. AES 2019, Abstract 2.141.